The pathogenic basis of malaria

LH Miller, DI Baruch, K Marsh, OK Doumbo - Nature, 2002 - nature.com
Malaria is today a disease of poverty and underdeveloped countries. In Africa, mortality
remains high because there is limited access to treatment in the villages. We should follow …

Antigenic Variation in Plasmodium falciparum

A Scherf, JJ Lopez-Rubio, L Riviere - Annu. Rev. Microbiol., 2008 - annualreviews.org
The persistence of the human malaria parasite Plasmodium falciparum during blood stage
proliferation in its host depends on the successive expression of variant molecules at the …

Computational improvements reveal great bacterial diversity and high metal toxicity in soil

J Gans, M Wolinsky, J Dunbar - Science, 2005 - science.org
The complexity of soil bacterial communities has thus far confounded effective
measurement. However, with improved analytical methods, we show that the abundance …

Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

AJ Reid, AM Talman, HM Bennett, AR Gomes… - elife, 2018 - elifesciences.org
Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

JM Carlton, JH Adams, JC Silva, SL Bidwell, H Lorenzi… - Nature, 2008 - nature.com
The human malaria parasite Plasmodium vivax is responsible for 25–40% of the∼ 515
million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe …

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

JM Carlton, SV Angiuoli, BB Suh, TW Kooij, M Pertea… - Nature, 2002 - nature.com
Species of malaria parasite that infect rodents have long been used as models for malaria
disease research. Here we report the whole-genome shotgun sequence of one species …

Molecular aspects of severe malaria

Q Chen, M Schlichtherle… - Clinical microbiology …, 2000 - Am Soc Microbiol
Human infections with Plasmodium falciparum may result in severe forms of malaria. The
widespread and rapid development of drug resistance in P. falciparum and the resistance of …

Reticulocyte-binding protein homologue 5–an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

J Baum, L Chen, J Healer, S Lopaticki, M Boyle… - International journal for …, 2009 - Elsevier
Invasion of erythrocytes is a prerequisite in the life history of the malaria parasite. Members
of the reticulocyte-binding homologue family (PfRh) have been implicated in the invasion …

The immunological balance between host and parasite in malaria

K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes

J Stubbs, KM Simpson, T Triglia, D Plouffe, CJ Tonkin… - Science, 2005 - science.org
The malaria parasite, Plasmodium falciparum, exploits multiple ligand-receptor interactions,
called invasion pathways, to invade the host erythrocyte. Strains of P. falciparum vary in their …