Haematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective
treatment modality for monogenic disorders of the blood system such as primary …

The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …

The stem cell niche is composed of a specialized population of cells that plays an essential
role in regulating adult stem cell self-renewal and differentiation. In adults, osteoblasts …

Mobilization of hematopoietic stem and progenitor cells from the bone marrow into the
circulation by repetitive, daily stimulations with G-CSF alone, or in combination with …

Expression of microRNAs, a new class of noncoding RNAs that hybridize to target
messenger RNA and regulate their translation into proteins, has been recently demonstrated …

Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization of
ischemic tissue. Ex vivo expansion of EPCs might be useful for potential clinical cell therapy …

Mobilized peripheral blood is increasingly used instead of bone marrow as a source of
autologous hematopoietic stem/progenitor cells for ex vivo gene therapy. Here, we present …

Successful blood and marrow transplant (BMT), both autologous and allogeneic, requires
the infusion of a sufficient number of hematopoietic progenitor/stem cells (HPCs) capable of …

Retention of long-term repopulating hematopoietic stem cells (LT-HSCs) in the bone marrow
is essential for hematopoiesis and for protection from myelotoxic injury. We report that …

This article reviews stem cell-based strategies for spinal cord injury repair, and practical
issues concerning their translation to the clinic. Recent progress in the stem cell field …