As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …

Pharmaceutical co-crystals have gained significant attention in recent years as a promising
green and sustainable method for poorly soluble drugs to improve their solubility, stability …

Lower respiratory tract infections (LRTIs) are one of the fatal diseases of the lungs that have
severe impacts on public health and the global economy. The currently available antibiotics …

Pharmaceutical salt formation is the most preferred and effective method to enhance the
physicochemical properties of an active pharmaceutical ingredient (API) such as solubility …

As the development of novel antibiotics has been at a halt for several decades, chemically
enhancing existing drugs is a very promising approach to drug development. Herein, we …

The cocrystallization of the fluoroquinolones ciprofloxacin (cip), norfloxacin (nor), and
enrofloxacin (enro) with the α, ω-dicarboxylic acids glutaric acid (glu), adipic acid (adi) …

New salts of antibiotic drug ciprofloxacin (CIP) with pharmaceutically acceptable maleic
(Mlt), fumaric (Fum) and adipic (Adp) acids were obtained and their crystal structures were …

Enrofloxacin, a second-generation quinolone broad-spectrum antimicrobial, has limited
application because of its poor solubility. The purpose of this paper was to investigate the …

Hydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and
low permeability leading to poor oral absorption. The present work explores the …

This article describes the synthesis and characterization of new cocrystals of ciprofloxacin
with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a …