Targets, models and challenges in osteoarthritis research
S Thysen, FP Luyten… - Disease models & …, 2015 - journals.biologists.com
Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …
Neurological heterotopic ossification: current understanding and future directions
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue
following a neurological condition, of which the most common are brain and spinal cord …
following a neurological condition, of which the most common are brain and spinal cord …
A microphysiological model of bone development and regeneration
Endochondral ossification (EO) is an essential biological process than underpins how
human bones develop, grow, and heal in the event of a fracture. So much is unknown about …
human bones develop, grow, and heal in the event of a fracture. So much is unknown about …
Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression
Osteoarthritis (OA) is a prevalent aging-related joint disease lacking disease-modifying
therapies. Here, we identified an upregulation of circulating exosomal osteoclast (OC) …
therapies. Here, we identified an upregulation of circulating exosomal osteoclast (OC) …
miRNA‐221 and miRNA‐222 synergistically function to promote vascular calcification
NCW Mackenzie, KA Staines, D Zhu… - Cell biochemistry …, 2014 - Wiley Online Library
Vascular calcification shares many similarities with skeletal mineralisation and involves the
phenotypic trans‐differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic …
phenotypic trans‐differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic …
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway
F Yu, S Yu, L Sun, J Zuo, K Luo, M Wang, X Fu… - Journal of Hazardous …, 2024 - Elsevier
Kashin–Beck disease is an endemic joint disease characterized by deep chondrocyte
necrosis, and T-2 toxin exposure has been confirmed its etiology. This study investigated …
necrosis, and T-2 toxin exposure has been confirmed its etiology. This study investigated …
Alginate/acemannan-based beads loaded with a biocompatible ionic liquid as a bioactive delivery system
Combining biomacromolecules with green chemistry principles and clean technologies has
proven to be an effective approach for drug delivery, providing a prolonged and sustained …
proven to be an effective approach for drug delivery, providing a prolonged and sustained …
Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice
Surgery and critical illness often associate with cognitive decline. Surgical trauma or
infection can lead independently to learning and memory impairments via similar, but not …
infection can lead independently to learning and memory impairments via similar, but not …
Additive manufacturing of an elastic poly (ester) urethane for cartilage tissue engineering
Although a growing knowledge on the field of tissue engineering of articular cartilage exists,
reconstruction or in-vitro growth of functional hyaline tissue still represents an unmet …
reconstruction or in-vitro growth of functional hyaline tissue still represents an unmet …
[HTML][HTML] MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway
C Hou, Z Yang, Y Kang, Z Zhang, M Fu, A He, Z Zhang… - FEBS letters, 2015 - Elsevier
Cartilage generation and degradation are regulated by miRNAs. Our previous study has
shown altered expression of miR-193b in chondrogenic human adipose-derived …
shown altered expression of miR-193b in chondrogenic human adipose-derived …