Targets, models and challenges in osteoarthritis research

S Thysen, FP Luyten… - Disease models & …, 2015 - journals.biologists.com
Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …

Neurological heterotopic ossification: current understanding and future directions

RD Brady, SR Shultz, SJ McDonald, TJ O'Brien - Bone, 2018 - Elsevier
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue
following a neurological condition, of which the most common are brain and spinal cord …

A microphysiological model of bone development and regeneration

IT Whelan, R Burdis, S Shahreza… - …, 2023 - iopscience.iop.org
Endochondral ossification (EO) is an essential biological process than underpins how
human bones develop, grow, and heal in the event of a fracture. So much is unknown about …

Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression

J Liu, X Wu, J Lu, G Huang, L Dang, H Zhang, C Zhong… - Nature Aging, 2021 - nature.com
Osteoarthritis (OA) is a prevalent aging-related joint disease lacking disease-modifying
therapies. Here, we identified an upregulation of circulating exosomal osteoclast (OC) …

miRNA‐221 and miRNA‐222 synergistically function to promote vascular calcification

NCW Mackenzie, KA Staines, D Zhu… - Cell biochemistry …, 2014 - Wiley Online Library
Vascular calcification shares many similarities with skeletal mineralisation and involves the
phenotypic trans‐differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic …

T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway

F Yu, S Yu, L Sun, J Zuo, K Luo, M Wang, X Fu… - Journal of Hazardous …, 2024 - Elsevier
Kashin–Beck disease is an endemic joint disease characterized by deep chondrocyte
necrosis, and T-2 toxin exposure has been confirmed its etiology. This study investigated …

Alginate/acemannan-based beads loaded with a biocompatible ionic liquid as a bioactive delivery system

JM Gomes, SS Silva, LC Rodrigues, RL Reis - International Journal of …, 2023 - Elsevier
Combining biomacromolecules with green chemistry principles and clean technologies has
proven to be an effective approach for drug delivery, providing a prolonged and sustained …

Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice

N Terrando, T Yang, JK Ryu, PT Newton, C Monaco… - Molecular …, 2014 - Springer
Surgery and critical illness often associate with cognitive decline. Surgical trauma or
infection can lead independently to learning and memory impairments via similar, but not …

Additive manufacturing of an elastic poly (ester) urethane for cartilage tissue engineering

S Camarero-Espinosa, A Calore, A Wilbers, J Harings… - Acta biomaterialia, 2020 - Elsevier
Although a growing knowledge on the field of tissue engineering of articular cartilage exists,
reconstruction or in-vitro growth of functional hyaline tissue still represents an unmet …

[HTML][HTML] MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway

C Hou, Z Yang, Y Kang, Z Zhang, M Fu, A He, Z Zhang… - FEBS letters, 2015 - Elsevier
Cartilage generation and degradation are regulated by miRNAs. Our previous study has
shown altered expression of miR-193b in chondrogenic human adipose-derived …