Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Oxygen availability varies throughout the human body in health and disease. Under
physiological conditions, oxygen availability drops from the lungs over the blood stream …

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …

Objective A comprehensive immune landscape for HBV infection is pivotal to achieve HBV
cure. Design We performed single-cell RNA sequencing of 2 43 000 cells from 46 paired …

Background & Aims Factors associated with a successful outcome upon nucleos (t) ide
analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients …

Disclosures: LJ Pallett reported personal fees from Gilead Sciences outside the submitted
work. OE Amin reported grants from Gilead Sciences outside the submitted work. X. Forns …

Transcatheter arterial chemoembolization (TACE) is widely used for the treatment of
advanced hepatocellular carcinoma (HCC). However, the long-term hypoxic …

Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …

Background & Aims Pyruvate dehydrogenase (PDC)-E2 specific CD8+ T cells play a leading
role in biliary destruction in PBC. However, there are limited data on the characterization of …

Oxygen (O2) is essential for cellular metabolism and biochemical reactions. When the
demand for O2 exceeds the supply, hypoxia occurs. Hypoxia-inducible factors (HIFs) are …