Effect of estrous cycle on behavior of females in rodent tests of anxiety

TA Lovick, H Zangrossi Jr - Frontiers in psychiatry, 2021 - frontiersin.org
Anxiety disorders are more prevalent in women than in men. In women the menstrual cycle
introduces another variable; indeed, some conditions eg, premenstrual syndrome, are …

Estrous cycle mediates midbrain neuron excitability altering social behavior upon stress

MR Shanley, Y Miura, CA Guevara… - Journal of …, 2023 - Soc Neuroscience
The estrous cycle is a potent modulator of neuron physiology. In rodents, in vivo ventral
tegmental area (VTA) dopamine (DA) activity has been shown to fluctuate across the estrous …

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

J Roa, M Ruiz-Cruz, F Ruiz-Pino, R Onieva… - Nature …, 2022 - nature.com
Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their
molecular regulatory mechanisms remain unfolded. Here, we report that congenital ablation …

Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy

J Li, LK Leverton, LM Naganatanahalli… - Experimental …, 2020 - Elsevier
Women with catamenial epilepsy often experience increased seizure burden near the time
of ovulation (periovulatory) or menstruation (perimenstrual). To date, a rodent model of …

Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice

CA Cutia, LK Leverton, X Ge, R Youssef… - Experimental …, 2022 - Elsevier
Clinical evidence indicates that patients with temporal lobe epilepsy (TLE) often show
differential outcomes of comorbid conditions in relation to the lateralization of the seizure …

Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport

L van Rosmalen, J Zhu, G Maier, EG Gacasan, T Lin… - Cell metabolism, 2024 - cell.com
Insufficient energy intake to meet energy expenditure demands of physical activity can result
in systemic neuroendocrine and metabolic abnormalities in activity-dependent anorexia and …

Automated classification of estrous stage in rodents using deep learning

NS Wolcott, KK Sit, G Raimondi, T Hodges… - Scientific reports, 2022 - nature.com
The rodent estrous cycle modulates a range of biological functions, from gene expression to
behavior. The cycle is typically divided into four stages, each characterized by distinct …

[HTML][HTML] Low dose exposure to dioxins alters hepatic energy metabolism and steatotic liver disease development in a sex-specific manner

OE Bolatimi, Y Hua, FA Ekuban, TC Gripshover… - Environment …, 2024 - Elsevier
Abstract “Dioxins” are persistent organic pollutants (POPs) that are continuously present in
the environment at appreciable levels and have been associated with increased risk of …

[HTML][HTML] Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle …

RJ Ingram, LK Leverton, VC Daniels, J Li… - Neurobiology of …, 2022 - Elsevier
Patients with epilepsy develop reproductive endocrine comorbidities at a rate higher than
that of the general population. Clinical studies have identified disrupted luteinizing hormone …

Sex and estrous cycle stage shape left-right asymmetry in chronic hippocampal seizures in mice

CA Cutia, LK Leverton, CA Christian-Hinman - Eneuro, 2023 - eneuro.org
Lateralization of hippocampal function is indicated by varied outcomes of patients with
neurologic disorders that selectively affect one hemisphere of this structure, such as …