Store operated Ca2+ entry (SOCE) is a ubiquitous signalling module with established roles
in the immune system, secretion and muscle development. Recent evidence supports a …

Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse
cellular functions including cell survival, metabolism, and transcription. As a result …

Alzheimer's disease (AD) is the most common cause of age-related dementia. Neuronal
calcium homeostasis impairment may contribute to AD. Here we demonstrated that voltage …

Calcium (Ca2+) plays a central role in regulating many cellular processes and influences
cell survival. Several mechanisms can disrupt Ca2+ homeostasis to trigger cell death …

Background Dozens of transplants generated from pluripotent stem cells are currently in
clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible …

The stromal interaction molecules (STIMs) are the sarcoplasmic reticulum (SR) Ca 2+
sensors that trigger store-operated Ca 2+ entry (SOCE) in a variety of cell types. While …

Impairment of proteostasis network is one of the characteristic features of many age-related
neurodegenerative disorders including autosomal dominantly inherited Huntington's …

Neurons are highly specialised cells that need to relay information over long distances and
integrate signals from thousands of synaptic inputs. The complexity of neuronal function is …

A major advance in the study of Huntington's disease (HD) has been the development of
human disease models employing induced pluripotent stem cells (iPSCs) derived from …

The development of cell reprogramming technologies became a breakthrough in the
creation of new models of human diseases, including neurodegenerative pathologies. The …