[HTML][HTML] Cellular and molecular signaling towards T cell immunological self-tolerance

F Carbone, C Russo, A Colamatteo, C La Rocca… - Journal of Biological …, 2024 - Elsevier
The binding of a cognate antigen to T cell receptor (TCR) complex triggers a series of
intracellular events controlling T cell activation, proliferation and differentiation. Upon TCR …

Scalable CD45 and PD-1 Gene Knockout Protocols in T cell using CRISPR/Cas9 System for Improved Efficacy and Safety of CAR T cell Therapy

FM Abriana - 2024 - repository.i3l.ac.id
Chimeric Antigen Receptor (CAR) T cell therapy has revolutionised immunotherapy by
boosting T celldriven tumour cell destruction through specific antigen recognition. Despite its …