Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose

Y Zhu, J Zhang, W Zhang, W Mu - Biotechnology Advances, 2023 - Elsevier
Human milk oligosaccharides (HMOs), the third major solid component in breast milk, are
recognized as the first prebiotics for health benefits in infants. Sialylated HMOs are an …

Advances and challenges for obtaining human milk oligosaccharides: Extraction from natural sources and synthesis by intentional design

J Gan, C Cao, B Stahl, X Zhao, J Yan - Trends in Food Science & …, 2023 - Elsevier
Abstract Background Human milk oligosaccharides (HMOs) are a group of structurally
diverse unconjugated carbohydrates that are bioactive and functional beyond their important …

Metabolic Engineering of Escherichia coli for High-Level Production of Lacto-N-neotetraose and Lacto-N-tetraose

Y Liao, J Wu, Z Li, J Wang, L Yuan, C Lao… - Journal of Agricultural …, 2023 - ACS Publications
Lacto-N-neotetraose (LNnT) and lacto-N-tetraose (LNT) are important oligosaccharides
found in breast milk and are commonly used as nutritional supplements in infant formula. We …

Physiological effects, biosynthesis, and derivatization of key human milk tetrasaccharides, lacto-N-tetraose, and lacto-N-neotetraose

Y Zhu, G Luo, L Wan, J Meng, SY Lee… - Critical Reviews in …, 2022 - Taylor & Francis
Human milk oligosaccharides (HMOs) have recently attracted ever-increasing interest
because of their versatile physiological functions. In HMOs, two tetrasaccharides, lacto-N …

[HTML][HTML] Fucose-containing bacterial exopolysaccharides: Sources, biological activities, and food applications

M Xiao, X Ren, Y Yu, W Gao, C Zhu, H Sun, Q Kong… - Food Chemistry: X, 2022 - Elsevier
Bacterial exopolysaccharides are high molecular weight polysaccharides that are secreted
by a wide range of bacteria, with diverse structures and easy preparation. Fucose, fucose …

Reprint of: Advanced glycosidases as ingenious biosynthetic instruments

Z Mészáros, P Nekvasilová, P Bojarová, V Křen… - Biotechnology …, 2021 - Elsevier
Until recently, glycosidases, naturally hydrolyzing carbohydrate-active enzymes, have found
few synthetic applications in industry, being primarily used for cleaving unwanted …

Development of the digestive system in early infancy and nutritional management of digestive problems in breastfed and formula-fed infants

H Jiang, S Gallier, L Feng, J Han, W Liu - Food & function, 2022 - pubs.rsc.org
Food digestion and absorption in infants are closely related to early growth and long-term
health. Human milk and infant formula are the main food sources for 0–6 month-old infants …

Engineered microbial routes for human milk oligosaccharides synthesis

M Lu, I Mosleh, A Abbaspourrad - ACS Synthetic Biology, 2021 - ACS Publications
Human milk oligosaccharides (HMOs) are one of the important ingredients in human milk,
which have attracted great interest due to their beneficial effect on the health of newborns …

Infant formulae–Key components, nutritional value, and new perspectives

G Luo, Y Zhu, D Ni, J Chen, W Zhang, W Mu - Food Chemistry, 2023 - Elsevier
Breastfeeding is the most effective strategy for meeting the nutritional demands of infants,
whilst infant formulae are manufactured foods that mimic human milk and can be safely used …

High-Level Productivity of Lacto-N-neotetraose in Escherichia coli by Systematic Metabolic Engineering

M Hu, M Li, C Li, Y Luo, T Zhang - Journal of Agricultural and Food …, 2023 - ACS Publications
Lacto-N-neotetraose (LNnT) is a critical component of human milk oligosaccharides. This
study introduces a systems metabolic engineering method to produce LNnT in Escherichia …