Stress-induced EGFR trafficking: mechanisms, functions, and therapeutic implications
Epidermal growth factor receptor (EGFR) has fundamental roles in normal physiology and
cancer, making it a rational target for cancer therapy. Surprisingly, however, inhibitors that …
cancer, making it a rational target for cancer therapy. Surprisingly, however, inhibitors that …
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …
ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
F Shi, SE Telesco, Y Liu… - Proceedings of the …, 2010 - National Acad Sciences
ErbB3/HER3 is one of four members of the human epidermal growth factor receptor
(EGFR/HER) or ErbB receptor tyrosine kinase family. ErbB3 binds neuregulins via its …
(EGFR/HER) or ErbB receptor tyrosine kinase family. ErbB3 binds neuregulins via its …
A kinase-independent role for EGF receptor in autophagy initiation
The epidermal growth factor receptor (EGFR) is upregulated in numerous human cancers.
Inhibition of EGFR signaling induces autophagy in tumor cells. Here, we report an …
Inhibition of EGFR signaling induces autophagy in tumor cells. Here, we report an …
[HTML][HTML] Survival of cancer cells is maintained by EGFR independent of its kinase activity
Z Weihua, R Tsan, WC Huang, Q Wu, CH Chiu… - Cancer cell, 2008 - cell.com
Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase
associated with cell proliferation and survival, is overactive in many tumors of epithelial …
associated with cell proliferation and survival, is overactive in many tumors of epithelial …
Transforming p21ras mutants and c-ets-2 activate the cyclin d1 promoter through distinguishable regions (∗)
C Albanese, J Johnson, G Watanabe, N Eklund… - Journal of Biological …, 1995 - ASBMB
Several different oncogenes and growth factors promote G 1 phase progression. Cyclin D1,
the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of …
the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of …
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
We describe a strategy for comprehending signaling pathways that are active in lung cancer
cells and that are targeted by dasatinib using chemical proteomics to identify direct …
cells and that are targeted by dasatinib using chemical proteomics to identify direct …
Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid
N Hino, Y Okazaki, T Kobayashi, A Hayashi… - Nature …, 2005 - nature.com
We report a method of photo-cross-linking proteins in mammalian cells, which is based on
site-specific incorporation of a photoreactive amino acid, p-benzoyl-l-phenylalanine (p Bpa) …
site-specific incorporation of a photoreactive amino acid, p-benzoyl-l-phenylalanine (p Bpa) …
The secret life of kinases: functions beyond catalysis
Protein phosphorylation participates in the regulation of all fundamental biological
processes, and protein kinases have been intensively studied. However, while the focus …
processes, and protein kinases have been intensively studied. However, while the focus …
Mitogenic signaling via G protein-coupled receptors
T van Biesen, LM Luttrell, BE Hawes… - Endocrine …, 1996 - academic.oup.com
RECEPTORS coupled to heterotrimeric GTP-binding proteins (G proteins) comprise the
largest known family of cell surface receptors and mediate cellular responses to a diverse …
largest known family of cell surface receptors and mediate cellular responses to a diverse …