Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …

In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …

Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

Intravesical BCG instillation is the gold-standard adjuvant immunotherapy for patients with
high-risk non-muscle-invasive bladder cancer. However, the precise mechanism of action by …

Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Trimethylation of histone H3 lysine 4 (H3K4me3) at the promoters of actively transcribed
genes is a universal epigenetic mark and a key product of Trithorax group action. Here, we …

Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine
base in the context of CpG dinucleotides. This modification creates a binding site for MBD …

Background Macrophages are widely-distributed innate immune cells playing diverse roles
in various physiological and pathological processes. The primary function of macrophages …