Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore
up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek …

Tumor necrosis factor receptor superfamily member-12A (TNFRSF12A) plays a critical role
in inflammation and cell death. It is expressed in multiple tissues yet extremely low in normal …

Extracellular vesicles are encapsulated lipid nanoparticles secreted by a variety of cell types
in living organisms. They are known to carry proteins, metabolites, nucleic acids, and lipids …

The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to
increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the …

Liver fibrosis is a common consequence of chronic liver disease. Over time, liver fibrosis can
develop into liver cirrhosis. Current therapies for liver fibrosis are limited, and liver transplant …

BACKGROUND Chronic hepatitis C virus (HCV) infection induces profound alterations in the
cytokine and chemokine signatures in peripheral blood. Clearance of HCV by antivirals …

Cystic fibrosis liver disease (CFLD) in children causes progressive fibrosis leading to biliary
cirrhosis; however, its cause (s) and early pathogenesis are unclear. We hypothesized that a …

Complications of end-stage chronic liver disease signify a major cause of mortality
worldwide. Irrespective of the underlying cause, most chronic liver diseases are …

During massive liver injury and hepatocyte loss, the intrinsic regenerative capacity of the
liver by replication of resident hepatocytes is overwhelmed. Treatment of this condition …