The release of insulin from pancreatic islets requires negative regulation to ensure low
levels of insulin release under resting conditions, as well as positive regulation to facilitate …

Type 2 diabetes has been coined “a two-hit disease,” as it involves specific defects of
glucose-stimulated insulin secretion from the pancreatic beta cells in addition to defects in …

The lipid‐lowering agent pravastatin and the antidepressant paroxetine are among the most
widely prescribed drugs in the world. Unexpected interactions between them could have …

Objective: To determine whether the PNPLA3 variant alters the susceptibility of morbidly
obese subjects to develop liver injury and metabolic sequelae. Participants and methods …

Reduced insulin release has been linked to defect exocytosis in β-cells. However, whether
expression of genes suggested to be involved in the exocytotic process (exocytotic genes) is …

As one of the leading causes of morbidity and mortality worldwide, diabetes affects an
estimated 422 million adults, and it is expected to continue expanding such that by 2050 …

Members of the soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor
(SNARE) family mediate membrane fusion processes associated with vesicular trafficking …

Obesity is recognized as a major health problem worldwide. Genetic factors play a major
role in obesity, and genomewide association studies have provided evidence that several …

Diabetes remains one of the leading causes of morbidity and mortality worldwide, affecting
an estimated 422 million adults. In the US, it is predicted that one in every three children …

SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of
insulin from pancreatic β cells. The protein exists as two alternatively spliced isoforms, SNAP …