▪ Abstract The hypocretins (orexins) are two novel neuropeptides (Hcrt-1 and Hcrt-2),
derived from the same precursor gene, that are synthesized by neurons located exclusively …

Since their discovery in 1998, the hypocretins (orexins)—peptides that are produced by a
group of neurons situated in the posterolateral hypothalamus—have been shown to excite …

Although maintained by multiple arousal systems, wakefulness falters if orexin (hypocretin),
orexin receptors, or orexin neurons are deficient; narcolepsy results with hypersomnolence …

To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in
maintaining wakefulness (W), we characterized the behavioral and sleep–wake phenotypes …

Neurons containing the neuropeptide melanin-concentrating hormone (MCH) are mainly
located in the lateral hypothalamus and the incerto-hypothalamic area, and have …

The hypocretins (orexins) are recently discovered neuropeptides initially associated with
feeding behavior and sleep regulation. However, the normal function of these peptides is …

Dysfunction of the hypocretin/orexin (Hcrt/Orx) peptide system is closely linked to the sleep
disorder narcolepsy, suggesting that it is also central to the normal regulation of sleep and …

Orexin (ORX) A and B (hypocretins) are excitatory neuropeptides produced by neurons of
the lateral hypothalamus that have been implicated in the regulation of the sleep–wake …

Orexin (hypocretin), is a neuropeptide produced by a subset of neurons in the lateral
hypothalamus. From the lateral hypothalamus, the orexin-containing neurons project their …

The hypocretinergic system has been implicated in the generation and/or maintenance of
wakefulness. Our results challenge this hypothesis. Utilizing cats as an animal model and …