Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …

Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations.
Unfortunately, no cellular models could be generated because the mutant cells have lower …

In the present review, we focus on the phenomenon of chromothripsis, a new type of
complex chromosomal rearrangements. We discuss the challenges of chromothripsis …

Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are
associated with a range of symptoms and significant morbidity. Despite extensive research …

We performed a comparative cytogenomic analysis of cultured and uncultured uterine
leiomyoma (UL) samples. The experimental approach included karyotyping, aCGH …

In the present study, we aimed to check whether uterine leiomyomas (ULs) with an
apparently normal karyotype in vitro comprise “hidden” cell subpopulations with numerical …

Background/Aim: Benign smooth-muscle tumors, leiomyomas, occur in nearly every organ
but are most common in the uterus. Whereas much is known about the genetics of uterine …

This paper suggests an approach for the use of a single paucicellular histological sample to
investigate two characteristics indicative of the cell's functional potential: 1) the content of …