To achieve good metabolic control in diabetes and keep long term, a combination of
changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal …

Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

Despite US Food and Drug Administration (FDA) approval of over 40 new treatment options
for type 2 diabetes since 2005, the latest data from the National Health and Nutrition …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors improve glycaemia in
patients with type 2 diabetes by enhancing urinary glucose excretion. We compared the …

OBJECTIVE To assess the efficacy of curcumin in delaying development of type 2 diabetes
mellitus (T2DM) in the prediabetic population. RESEARCH DESIGN AND METHODS This …

Aims/hypothesis The aim of this work was to evaluate the efficacy and safety of canagliflozin
vs placebo and sitagliptin in patients with type 2 diabetes who were being treated with …

OBJECTIVE To evaluate the efficacy and safety of canagliflozin, a sodium glucose
cotransporter 2 inhibitor, compared with sitagliptin in subjects with type 2 diabetes …

Background Rosiglitazone is an insulin sensitiser used in combination with metformin, a
sulfonylurea, or both, for lowering blood glucose in people with type 2 diabetes. We …

OBJECTIVE Although initially effective, sulfonylureas are associated with poor glycemic
durability, weight gain, and hypoglycemia. Dapagliflozin, a selective inhibitor of sodium …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on oral pharmacologic treatment of type …