Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches

M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …

DNA damage repair pathways in prostate cancer: a narrative review of molecular mechanisms, emerging biomarkers and therapeutic targets in precision oncology

IM Grypari, V Tzelepi, K Gyftopoulos - International Journal of Molecular …, 2023 - mdpi.com
Prostate cancer (PCa) has a distinct molecular signature, including characteristic
chromosomal translocations, gene deletions and defective DNA damage repair …

Intracellular regulation of zinc by metal–organic framework-mediated genome editing for prostate cancer therapy

Y Xue, H Tang, G Chen, Y Pan, D Li, Y Ping - Biomaterials Science, 2023 - pubs.rsc.org
Normal prostate tissues generally exhibit a higher level of zinc to maintain their special
“citrate-producing” metabolism, while its level dramatically decreases during prostate …

Oleocanthal attenuates metastatic castration-resistant prostate cancer progression and recurrence by targeting SMYD2

AB Siddique, HY Ebrahim, A Tajmim, JA King… - Cancers, 2022 - mdpi.com
Simple Summary The Mediterranean, extra-virgin-olive-oil-rich diet ingredient S-(-)-
oleocanthal (OC) has emerged as a potential inhibitor for the growth and relapse of the most …

Review on the role of BRCA mutations in genomic screening and risk stratification of prostate cancer

N Kalampokis, C Zabaftis, T Spinos, M Karavitakis… - Current …, 2024 - mdpi.com
(1) Background: Somatic and germline alterations can be commonly found in prostate
cancer (PCa) patients. The aim of our present study was to perform a comprehensive review …

Barriers, interventions, and recommendations: Improving the genetic testing landscape

EJ Dusic, T Theoryn, C Wang, EM Swisher… - Frontiers in Digital …, 2022 - frontiersin.org
Individual, provider, clinic, and societal level barriers have been shown to undermine the
potential impact of genetic testing. The current approach in the primary care setting places …

[HTML][HTML] Clinical and functional analyses of an African-ancestry gain-of-function HOXB13 variant implicated in aggressive prostate cancer

M Kanayama, Y Chen, D Rabizadeh, L Vera… - European Urology …, 2023 - Elsevier
Background Recent reports have uncovered a HOXB13 variant (X285K) predisposing to
prostate cancer in men of West African ancestry. The clinical relevance and protein function …

MicroRNA-32 suppression: Its effects on prostate cancer cells' capability to proliferate and migrate

FA Al-Marzook, DM Hassan, MW Alghazal… - Drug …, 2023 - thieme-connect.com
Introduction This paper sought to scrutinize the role of microRNA-32 (miR-32) on the growth
and migration as well as on the expression of metastatic genes in PC3 cells of prostate …

Role of N6‑methyladenosine in the pathogenesis, diagnosis and treatment of prostate cancer

J Pan, F Tong, N Ren, L Ren, Y Yang… - Oncology …, 2024 - spandidos-publications.com
Prostate cancer (PCa) affects males of all racial and ethnic groups, and leads to higher rates
of mortality in those belonging to a lower socioeconomic status due to the late detection of …

Rare Genetic Drivers of Lethal Prostate Cancer

AW Wyatt - JAMA oncology, 2023 - jamanetwork.com
Genetic testing is a recently adopted standard of care for male patients with metastatic or
high-risk localized prostate cancer. 1 Rare deleterious germline alterations in a small …