Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

C Hu, C Chu, L Liu, C Wang, S Jin, R Yang, S Rung… - Science …, 2021 - science.org
The structural properties of biomaterials play crucial roles in guiding cell behavior and
influencing immune responses against the material. We fabricated electrospun membranes …

Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease

C Barnig, T Bezema, PC Calder, A Charloux… - Frontiers in …, 2019 - frontiersin.org
Formerly considered as a passive process, the resolution of acute inflammation is now
recognized as an active host response, with a cascade of coordinated cellular and …

Gut macrophages: key players in intestinal immunity and tissue physiology

PA Muller, F Matheis, D Mucida - Current opinion in immunology, 2020 - Elsevier
Highlights•Distinct populations of intestinal macrophages segregated both transcriptionally
and anatomically, exist in the mouse and human.•The intestine hosts long-lived macrophage …

A clinical approach for the use of VIP axis in inflammatory and autoimmune diseases

C Martínez, Y Juarranz, I Gutiérrez-Cañas… - International Journal of …, 2019 - mdpi.com
The neuroendocrine and immune systems are coordinated to maintain the homeostasis of
the organism, generating bidirectional communication through shared mediators and …

Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA …

WB Wang, JT Li, Y Hui, J Shi, XY Wang, SG Yan - Chinese Medicine, 2022 - Springer
Background Acute lung injury (ALI) is an acute multifactorial infectious disease induced by
trauma, pneumonia, shock, and sepsis. This study aimed to investigate the protective effects …

[HTML][HTML] Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease

M El-Salhy, T Solomon, T Hausken… - World journal of …, 2017 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a chronic recurrent condition whose etiology is
unknown, and it includes ulcerative colitis, Crohn's disease, and microscopic colitis. These …

The anti‐inflammatory mediator, vasoactive intestinal peptide, modulates the differentiation and function of Th subsets in rheumatoid arthritis

R Villanueva-Romero, I Gutiérrez-Cañas… - Journal of …, 2018 - Wiley Online Library
Genetic background, epigenetic modifications, and environmental factors trigger
autoimmune response in rheumatoid arthritis (RA). Several pathogenic infections have been …

Nerve–macrophage interactions in cardiovascular disease

K Fujiu, I Manabe - International immunology, 2022 - academic.oup.com
The heart is highly innervated by autonomic neurons, and dynamic autonomic regulation of
the heart and blood vessels is essential for animals to carry out the normal activities of life …

Do neuroendocrine peptides and their receptors qualify as novel therapeutic targets in osteoarthritis?

S Grässel, D Muschter - International journal of molecular sciences, 2018 - mdpi.com
Joint tissues like synovium, articular cartilage, meniscus and subchondral bone, are targets
for neuropeptides. Resident cells of these tissues express receptors for various …

The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy

H Zhang, T Passang, S Ravindranathan… - Frontiers in …, 2023 - frontiersin.org
In the past decades, advances in the use of adoptive cellular therapy to treat cancer have
led to unprecedented responses in patients with relapsed/refractory or late-stage …