Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

The function of B cells in Alzheimer's disease (AD) is not fully understood. While
immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and …

Alzheimer's disease (AD) is characterized by plaques containing amyloid-β (Aβ) and
neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and …

Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …

Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The
mechanisms underlying synapse loss have been extensively investigated using mouse …

Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …

Diabetic retinopathy (DR) is a neurovascular complication of diabetes. Recent investigations
have suggested that early degeneration of the neuroretina may occur prior to the …

Microglia cells are active players in regulating synaptic development and plasticity in the
brain. However, how they influence the normal functioning of synapses is largely unknown …

Unraveling the fine structure of the brain is important to provide a better understanding of its
normal and abnormal functioning. Application of high-resolution electron microscopic …