Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in
low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic …

One of the most compelling needs in the study of Alzheimer's disease (AD) is the
characterization of cognitive decline peripheral biomarkers. In this context, the theme of …

Mutations in the gene MYOC account for approximately 5% of cases of primary open angle
glaucoma (POAG). MYOC encodes for the protein myocilin, a multimeric secreted …

Widespread testing for the presence of the novel coronavirus severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID …

Long non-coding RNAs (lncRNAs) are involved in many neurological conditions, and
neurodegenerative disorders including Alzheimer's disease (AD) regulate gene expression …

Glaucoma-associated myocilin is a member of the olfactomedins, a protein family involved in
neuronal development and human diseases. Molecular studies of the myocilin N-terminal …

Myocilin is secreted from trabecular meshwork cells to an eponymous extracellular matrix
that is critical for maintaining intraocular pressure. Missense mutations found in the myocilin …

Myocilin (MYOC) was discovered more than 20 years ago and is the gene whose mutations
are most commonly observed in individuals with glaucoma. Despite extensive research …

Nonsynonymous gene mutations can be beneficial, neutral, or detrimental to the stability,
structure, and biological function of the encoded protein, but the effects of these mutations …

MYOC is a common pathogenic gene for primary open-angle glaucoma and encodes the
protein named myocilin. Multiple MYOC variations have been found, with different clinical …