Antibiotic Resistance to Mycobacterium tuberculosis and Potential Use of Natural and Biological Products as Alternative Anti-Mycobacterial Agents
R Arrigoni, A Ballini, S Topi, L Bottalico, E Jirillo… - Antibiotics, 2022 - mdpi.com
Background: Tuberculosis (TB) is an infectious disease caused by the bacillus
Mycobacterium tuberculosis (Mtb). TB treatment is based on the administration of three …
Mycobacterium tuberculosis (Mtb). TB treatment is based on the administration of three …
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
DM Hoi, S Junker, L Junk, K Schwechel, K Fischel… - Cell, 2023 - cell.com
Summary The ClpC1: ClpP1P2 protease is a core component of the proteostasis system in
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …
Patenting perspective of modulators of ClpP endopeptidase: 2019-present
Z Wang, L He, Z Fan, Y Luo - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
Introduction ClpP is a highly conserved serine protease that plays a crucial role in
maintaining protein homeostasis in both bacterial cells and human mitochondria. Several …
maintaining protein homeostasis in both bacterial cells and human mitochondria. Several …
[HTML][HTML] Design and synthesis of Acyldepsipeptide-1 analogues: Antibacterial activity and cytotoxicity screening
SZZ Cobongela, MM Makatini… - Arabian Journal of …, 2023 - Elsevier
Acyldepsipeptides (ADEPs) are receiving more attention as prospective antimicrobial agents
due to their unique mode of action and chemical properties. However, their therapeutic …
due to their unique mode of action and chemical properties. However, their therapeutic …
Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein …
J Key, S Gispert, G Auburger - Genes, 2024 - mdpi.com
LONP1 is the principal AAA+ unfoldase and bulk protease in the mitochondrial matrix, so its
deletion causes embryonic lethality. The AAA+ unfoldase CLPX and the peptidase CLPP …
deletion causes embryonic lethality. The AAA+ unfoldase CLPX and the peptidase CLPP …
Bacterial Antimicrobial Peptides: A Potential Alternative to Antibiotics
S Kumari, A Kumari - Evolution of Antimicrobial Peptides: From Self …, 2024 - Springer
Numerous infectious diseases have become more difficult to cure because of the global
spread of antibiotic-resistant microbes. This perilous position is exacerbated by the fact that …
spread of antibiotic-resistant microbes. This perilous position is exacerbated by the fact that …
[图书][B] Characterization of the in Vivo Mechanisms of Action of Cell Envelope Targeting Antibiotics
AB Schäfer - 2024 - research.chalmers.se
This dissertation was submitted for the partial fulfilment of the degree of Doctor of
Philosophy. The original work presented in this dissertation was carried out between …
Philosophy. The original work presented in this dissertation was carried out between …
[图书][B] Antibiotics and Secondary Metabolites Analysis SHell (antiSMASH) as a Tool to Detect Putative Novel Antibiotics
R Snape - 2023 - search.proquest.com
Abstract In the Hudson Lab, which is focused on discovering new antibiotics, bacteria
samples are taken from the environment and cultured in large quantities. Then they are …
samples are taken from the environment and cultured in large quantities. Then they are …