As double membrane‐encapsulated nanovesicles (30‐150 nm), exosomes (Exos) shuttle
between different cells to mediate intercellular communication and transport active cargoes …

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is a group of chronic inflammatory diseases of the gastrointestinal tract. Repeated …

The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies
followed by anti-integrins and anti-interleukins has drastically changed the treatment …

Guhong injection (GHI) can be used for the treatment of ischemic stroke. We investigated the
antiapoptotic activity of GHI, its ability to repair the cerebral microvessels and mitochondria …

Fibrosis is a common problem in soft tissue regeneration, often caused by the differentiation
of fibroblasts into myofibroblasts. Because of the nanoscale topology that regulates the …

Heart disease remains an increasing major public health challenge in the United States and
worldwide. A common end-organ feature in diseased hearts is myocardial fibrosis, which …

The placenta is an organ that is discarded after childbirth. Recently, mesenchymal stem cells
(MSCs) isolated from various parts of the placenta (PMSCs) are established as a rich …

Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as
“molecular switch” in cellular signaling regulation processes and are associated with the …

Background A significant unmet need in inflammatory bowel disease is the lack of anti-
fibrotic agents targeting intestinal fibrosis. This study aimed to investigate the anti-fibrogenic …

Bowel strictures are well recognized as one of the most severe complications in Crohn's
disease, with variable impacts on the prognosis and often needing surgical or endoscopic …