Mesenchymal Stem Cell‐derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases
C Tian, M Yang, H Xu, M Zhu, Y Zhang… - Stem cells …, 2023 - Wiley Online Library
As double membrane‐encapsulated nanovesicles (30‐150 nm), exosomes (Exos) shuttle
between different cells to mediate intercellular communication and transport active cargoes …
between different cells to mediate intercellular communication and transport active cargoes …
Stem cell therapy in inflammatory bowel disease: a review of achievements and challenges
CM Tian, Y Zhang, MF Yang, HM Xu… - Journal of …, 2023 - Taylor & Francis
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is a group of chronic inflammatory diseases of the gastrointestinal tract. Repeated …
(UC), is a group of chronic inflammatory diseases of the gastrointestinal tract. Repeated …
[HTML][HTML] Fibrostenotic strictures in Crohn's disease
The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies
followed by anti-integrins and anti-interleukins has drastically changed the treatment …
followed by anti-integrins and anti-interleukins has drastically changed the treatment …
Guhong injection protects against apoptosis in cerebral ischemia by maintaining cerebral microvasculature and mitochondrial integrity through the PI3K/AKT pathway
H Zhou, Y He, J Zhu, X Lin, J Chen, C Shao… - Frontiers in …, 2021 - frontiersin.org
Guhong injection (GHI) can be used for the treatment of ischemic stroke. We investigated the
antiapoptotic activity of GHI, its ability to repair the cerebral microvessels and mitochondria …
antiapoptotic activity of GHI, its ability to repair the cerebral microvessels and mitochondria …
Constructing nanoscale topology on the surface of microfibers inhibits fibroblast fibrosis
Y Jiao, X Li, J Chen, C Li, L Liu, X Liu, F Wang… - Advanced Fiber …, 2022 - Springer
Fibrosis is a common problem in soft tissue regeneration, often caused by the differentiation
of fibroblasts into myofibroblasts. Because of the nanoscale topology that regulates the …
of fibroblasts into myofibroblasts. Because of the nanoscale topology that regulates the …
Extracellular vesicles as therapeutic agents for cardiac fibrosis
Heart disease remains an increasing major public health challenge in the United States and
worldwide. A common end-organ feature in diseased hearts is myocardial fibrosis, which …
worldwide. A common end-organ feature in diseased hearts is myocardial fibrosis, which …
Placenta‐derived mesenchymal stem cells for treatment of diseases: a clinically relevant source
The placenta is an organ that is discarded after childbirth. Recently, mesenchymal stem cells
(MSCs) isolated from various parts of the placenta (PMSCs) are established as a rich …
(MSCs) isolated from various parts of the placenta (PMSCs) are established as a rich …
Role of Rho GTPases in inflammatory bowel disease
X Li, M Zhang, G Zhou, Z Xie, Y Wang, J Han, L Li… - Cell Death …, 2023 - nature.com
Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as
“molecular switch” in cellular signaling regulation processes and are associated with the …
“molecular switch” in cellular signaling regulation processes and are associated with the …
Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro
YJ Choi, WR Kim, DH Kim, JH Kim, JH Yoo - Stem Cell Research & …, 2024 - Springer
Background A significant unmet need in inflammatory bowel disease is the lack of anti-
fibrotic agents targeting intestinal fibrosis. This study aimed to investigate the anti-fibrogenic …
fibrotic agents targeting intestinal fibrosis. This study aimed to investigate the anti-fibrogenic …
Fibrostenosing Crohn's Disease: Pathogenetic Mechanisms and New Therapeutic Horizons
I Mignini, V Blasi, F Termite, G Esposto… - International Journal of …, 2024 - mdpi.com
Bowel strictures are well recognized as one of the most severe complications in Crohn's
disease, with variable impacts on the prognosis and often needing surgical or endoscopic …
disease, with variable impacts on the prognosis and often needing surgical or endoscopic …