Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

Doxorubicin targets multiple players: a new view of an old problem

D Cappetta, F Rossi, E Piegari, F Quaini… - Pharmacological …, 2018 - Elsevier
Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer
survivors, and the advancement of cardio-oncology is a necessary step for an effective care …

Inflammatory markers in ST-elevation acute myocardial infarction

IM Seropian, C Sonnino… - European Heart …, 2016 - journals.sagepub.com
After acute myocardial infarction, ventricular remodeling is characterized by changes at the
molecular, structural, geometrical and functional level that determine progression to heart …

Doxorubicin cardiotoxicity and target cells: a broader perspective

A De Angelis, K Urbanek, D Cappetta, E Piegari… - Cardio-Oncology, 2016 - Springer
The cardiotoxicity of doxorubicin is becoming an interdisciplinary point of interest given a
growing population of cancer survivors. The complex and not completely understood …

Comparison of different bone marrow–derived stem cell approaches in reperfused STEMI: a multicenter, prospective, randomized, open-labeled TECAM trial

JA San Roman, PL Sánchez, A Villa… - Journal of the American …, 2015 - jacc.org
Background: Stem cell–based therapy has emerged as a potential therapy in acute
myocardial infarction (AMI). Although various approaches have been studied, intracoronary …

Diabetes limits stem cell mobilization following G-CSF but not plerixafor

GP Fadini, M Fiala, R Cappellari, M Danna, S Park… - Diabetes, 2015 - Am Diabetes Assoc
Previous studies suggest that diabetes impairs hematopoietic stem cell (HSC) mobilization
in response to granulocyte colony-stimulating factor (G-CSF). In this study, we tested …

[HTML][HTML] Stem cells and heart disease-Brake or accelerator?

G Steinhoff, J Nesteruk, M Wolfien, J Grosse… - Advanced drug delivery …, 2017 - Elsevier
After two decades of intensive research and attempts of clinical translation, stem cell based
therapies for cardiac diseases are not getting closer to clinical success. This review tries to …

Stem cell therapy against ischemic heart disease

IT Tsai, CK Sun - International Journal of Molecular Sciences, 2024 - mdpi.com
Ischemic heart disease, which is one of the top killers worldwide, encompasses a series of
heart problems stemming from a compromised coronary blood supply to the myocardium …

Pharmacological elevation of circulating bioactive phosphosphingolipids enhances myocardial recovery after acute infarction

YM Klyachkin, PR Nagareddy, S Ye… - Stem Cells …, 2015 - academic.oup.com
Acute myocardial infarction (AMI) triggers mobilization of bone marrow (BM)-derived
stem/progenitor cells (BMSPCs) through poorly understood processes. Recently, we …