A novel series of 1-(2, 4-dimethoxy-phenyl)-3-(1, 3-diphenyl-1H-pyrazol-4-yl)-propenone (3)
have been prepared by the Claisen–Schmidt condensation of 1-(2, 4-dimethoxy-phenyl) …

Non‐steroidal anti‐inflammatory drugs are among the most widely used therapeutics,
primarily for the treatment for pain and inflammation. Prostaglandins mediate a number of …

NSAIDs are among the most widely prescribed medications across the world, but the
gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current …

Prostaglandins (PGs) are powerful lipid mediators in many physiological and
pathophysiological responses. They are produced by oxidation of arachidonic acid (AA) by …

A new series of N′-(substituted phenyl)-2-(1-(4-(methylsulfinyl) benzylidene)− 5-fluoro-2-
methyl-1 H-inden-3-yl) acetohydrazide derivatives (1–25) were prepared in good yields in …

This study aimed to explore the mechanisms of action of a sulindac acetohydrazide
derivative, N'-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-fluoro-2 …

The synthesis and the pharmacological activity of a series of 1‐aroyl derivatives of kynurenic
acid methyl ester (4‐oxo‐quinolin‐2‐carboxy methyl (KYNA) esters), structurally related to …

Non-steroidal anti-inflammatory drugs (NSAIDs) are an important class of therapeutics,
incorporate a heterocyclic core in their molecular structure and are used for the alleviation of …

Target delivery and controlled release of the chemopreventive drug sulindac that possesses
low water solubility present a great challenge for its pharmaceutical industry. Here, we …

Disclosed are compounds, for example, compounds of for mula (I),(Formula (I) wherein R,
Ro, R-Rg, n, X, Y, Y', and E are as described herein, pharmaceutical compositions …