The overall efficacy of chimeric antigen receptor modified T cells (CARTs) remain limited in
solid tumors despite intensive studies that aim at targeting multiple antigens, enhancing …

Digestive tract cancers (DTC) belong to the most investigated family of tumors. The
incidence, prevalence, and mortality rate of DTC remain high, especially for patients with …

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of
malignant and non-malignant disorders. CARs are synthetic transmembrane receptors …

Simple Summary Gastric cancer (GC) is one of the most common and deadly cancers
globally, rendering the development of novel therapeutic strategies an urgent priority …

Claudins (CLDNs) are a multigene family of proteins and the principal components of tight
junctions (TJs), which normally mediate cell–cell adhesion and selectively allow the …

Abstract Claudin-18.2 (CLDN18. 2) is a member of the tight junction protein family and is a
highly selective biomarker with often abnormal expression during the occurrence and …

Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook
and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it …

Gastric cancer and gastroesophageal junction cancer represent the leading cause of tumor-
related death worldwide. Although advances in immunotherapy and molecular targeted …

Background Cancers of the upper gastrointestinal tract represent a lethal disease entity
comprising the esophagus, gastroesophageal junction, and stomach. The backbone of …

Gastroesophageal cancers (GECs) represent a significant clinical challenge. For early
resectable GEC, the integration of immune checkpoint inhibitors into the perioperative …