Reviewing the role of the orexinergic system and stressors in modulating mood and reward-related behaviors
In this review study, we aimed to introduce the orexinergic system as an important signaling
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …
Sleep-mediated regulation of reward circuits: implications in substance use disorders
Our modern society suffers from both pervasive sleep loss and substance abuse—what may
be the indications for sleep on substance use disorders (SUDs), and could sleep contribute …
be the indications for sleep on substance use disorders (SUDs), and could sleep contribute …
Cannabidiol efficiently suppressed the acquisition and expression of methamphetamine-induced conditioned place preference in the rat
M Anooshe, K Nouri, S Karimi-Haghighi… - Behavioural Brain …, 2021 - Elsevier
Methamphetamine (MET) is one of the most prevalently abused psychostimulants in the
world with drastic repercussions. Several studies emphasized the inhibitory effect of …
world with drastic repercussions. Several studies emphasized the inhibitory effect of …
Differential roles of intra-accumbal orexin receptors in acquisition and expression of methamphetamine-induced conditioned place preference in the rats
A large amount of document has revealed that the orexin system in the reward circuity,
including the nucleus accumbens (NAc), contributes to the modification of drug …
including the nucleus accumbens (NAc), contributes to the modification of drug …
Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats
A Matzeu, R Martin-Fardon - Neuropharmacology, 2020 - Elsevier
Prescription opioids, such as oxycodone, are potent analgesics that are used to treat and
manage pain. However, oxycodone is one of the most commonly abused prescription drugs …
manage pain. However, oxycodone is one of the most commonly abused prescription drugs …
Involvement of hippocampal D1-like dopamine receptors in the inhibitory effect of cannabidiol on acquisition and expression of methamphetamine-induced …
K Nouri, M Anooshe, S Karimi-Haghighi… - Neurochemical …, 2021 - Springer
Cannabidiol (CBD) is a non-psychotomimetic compound with strong potential to decrease
the psychostimulant's rewarding effect with unclear receptors. Furthermore, as a part of the …
the psychostimulant's rewarding effect with unclear receptors. Furthermore, as a part of the …
Systematic review: pain, cognition, and cardioprotection—unpacking oxytocin's contributions in a sport context
P Szabó, S Bonet, R Hetényi, D Hanna… - Frontiers in …, 2024 - frontiersin.org
Introduction This systematic review investigates the interplay between oxytocin and
exercise; in terms of analgesic, anti-inflammatory, pro-regenerative, and cardioprotective …
exercise; in terms of analgesic, anti-inflammatory, pro-regenerative, and cardioprotective …
Blockade of the orexin-2 receptors within the ventral tegmental area facilitates the extinction and prevents the reinstatement of methamphetamine-seeking behavior
F Zamanirad, K Eskandari, Z Mousavi… - Physiology & …, 2024 - Elsevier
Repeated use of methamphetamine (METH) causes severe effects on the central nervous
system, associated with an increased relapse rate. The orexinergic system is highly …
system, associated with an increased relapse rate. The orexinergic system is highly …
Melatonin blocks morphine-induced place preference: involvement of GLT-1, NF-κB, BDNF, and CREB in the nucleus accumbens
BS Alghamdi, FS Alshehri - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Opioid addiction remains a widespread issue despite continuous attempts by the FDA to
help maintain abstinence. Melatonin is a neurohormone considered to be involved only in …
help maintain abstinence. Melatonin is a neurohormone considered to be involved only in …
Pleasure, addiction, and hypocretin (orexin)
R McGregor, TC Thannickal, JM Siegel - Handbook of clinical neurology, 2021 - Elsevier
The hypocretins/orexins were discovered in 1998. Within 2 years, this led to the discovery of
the cause of human narcolepsy, a 90% loss of hypothalamic neurons containing these …
the cause of human narcolepsy, a 90% loss of hypothalamic neurons containing these …