Protein expression and function in eukaryotic cells are tightly harmonized processes
modulated by the combination of different layers of regulation, including transcription …

Regulating protein folding including assisting de novo folding, preventing misfolding and
aggregation, and facilitating refolding of proteins are of significant importance for retaining …

In recent work we proposed that interdiction in the earliest contact-formation events along
the folding pathway of key viral proteins could provide a novel avenue for therapeutic drug …

Angiotensin-converting enzyme 2 (ACE2) is the host cellular receptor that locks onto the
surface spike protein of the 2002 SARS coronavirus (SARS-CoV-1) and of the novel, highly …

Cell-based kinetic studies of ligand or candidate drug binding to membrane proteins have
produced affinity and kinetic values that are different from measurements using purified …

Since its first detection in 2019, the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS‐CoV‐2) has been the cause of millions of deaths worldwide. Despite the …

Deubiquitination is a reverse post-translational modification of ubiquitination and plays
significant roles in various signal transduction cascades and protein stability. The p53 is a …

In this article, we predict the folding initiation events of the ribose phosphatase domain of
protein Nsp3 and the receptor binding domain of the spike protein from the severe acute …

One type of liquid waste produced by Crude Palm Oil processing is Palm Oil Mill Effluent
(POME). This waste is a big challenge for the environment because of its dark brown color …

In recent work, we proposed that effective therapeutic drugs aimed at treating the SARS-CoV-
2 infection could be developed based on interdicting in the early steps of the folding …