Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …

Presenilin (PS) plays a central role in the pathogenesis of Alzheimer's disease, and loss of
PS causes progressive memory impairment and age-related neurodegeneration in the …

Background—A hallmark of heart failure is impaired cytoplasmic Ca2+ handling of
cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca2+ handling …

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …

Abnormal regulation of intracellular Ca2+ by sarcoplasmic reticulum plays a part in the
mechanism underlying contractile and relaxation dysfunction in heart failure (HF). The …

Introduction Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for
disease modeling. However, it is not invariably successful to recapitulate the disease …

Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are
Ca 2+-mobilizing messengers important for modulating cardiac excitation–contraction …

In many cell types the intracellular Ca2+ store performs a central role in the regulation of the
cytosolic Ca2+ concentration ([Ca2+] c), the elevation of which triggers diverse and …

Excitation-contraction coupling involves the faithful conversion of electrical stimuli to
mechanical shortening in striated muscle cells, enabled by the ubiquitous second …