A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins

SFH Shore, M Ptacek, AD Steen, EM Fozo - Msystems, 2024 - Am Soc Microbiol
Bacterial chromosomal type I toxin-antitoxin systems consist of a small protein, typically
under 60 amino acids, and a small RNA (sRNA) that represses toxin translation. These gene …

Mechanisms of action and synergies of a novel lipid IVA biosynthesis inhibitor

ER Holden, M Yasir, AK Turner, MA Webber, I Charles… - bioRxiv, 2023 - biorxiv.org
The development of novel antimicrobials provides additional treatment options for infectious
diseases, including antimicrobial resistant infections. There are many hurdles to …