Among the most studied diseases that affect the central nervous system are Parkinson's,
Alzheimer's, and Huntington's diseases, but the lack of effective biomarkers, accurate …

From yeast to humans, polyglutamine (polyQ) repeat tracts are found frequently in the
proteome and are particularly prominent in the activation domains of transcription factors …

RNA toxicity contributes to diseases caused by anomalous nucleotide repeat expansions.
Recent work demonstrated RNA-based toxicity from repeat-associated, non-AUG-initiated …

Metabolic changes are a major cause of pathophysiological alterations in
neurodegenerative diseases. Recent metabolic profiling studies have led to the …

Polyglutamine diseases are a group of nine inherited neurodegenerative diseases:
Huntington's disease (HD), Dentato-rubral pallidoluysian atrophy (DRPLA), spinal and …