[HTML][HTML] Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

MF Simões, RMA Pinto, S Simões - Drug Discovery Today, 2019 - Elsevier
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Stereolithography 3D printing technology in pharmaceuticals: a review

S Deshmane, P Kendre, H Mahajan… - Drug Development and …, 2021 - Taylor & Francis
Abstract Three-dimensional printing (3DP) technology is an innovative tool used in
manufacturing medical devices, producing alloys, replacing biological tissues, producing …

Formulation of 3D printed tablet for rapid drug release by fused deposition modeling: screening polymers for drug release, drug-polymer miscibility and printability

NG Solanki, M Tahsin, AV Shah… - Journal of pharmaceutical …, 2018 - Elsevier
The primary aim of this study was to identify pharmaceutically acceptable amorphous
polymers for producing 3D printed tablets of a model drug, haloperidol, for rapid release by …

[PDF][PDF] Formulation and evaluation of Carica papaya nanoemulsion for treatment of dengue and thrombocytopenia.

S Mandal, V Jaiswal, MK Sagar… - Plant Archives …, 2021 - plantarchives.org
Plant Archives Page 1 e-ISSN:2581-6063 (online), ISSN:0972-5210 Plant Archives Volume 21,
No 1, 2021 pp. 1345-1354 DOI Url: https://doi.org/10.51470/PLANTARCHIVES.2021.v21.no1.179 …

[HTML][HTML] Combining drug salt formation with amorphous solid dispersions–a double edged sword

TN Hiew, LS Taylor - Journal of Controlled Release, 2022 - Elsevier
Glass transition temperature (T g) is important for amorphous compounds because it can
have implications on their physical and chemical stability. With drugs that possess ionizable …

Tailoring immediate release FDM 3D printed tablets using a quality by design (QbD) approach

YM Than, V Titapiwatanakun - International Journal of Pharmaceutics, 2021 - Elsevier
The aims of this work were to produce immediate release printed tablets using fused
deposition modelling (FDM) technique and to systematically explore the effects of different …

Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance

Q Shi, H Chen, Y Wang, R Wang, J Xu, C Zhang - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Effects of surfactants on itraconazole-HPMCAS solid dispersion prepared by hot-melt extrusion I: Miscibility and drug release

NG Solanki, K Lam, M Tahsin, SG Gumaste… - Journal of …, 2019 - Elsevier
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has been widely investigated
as a carrier for amorphous solid dispersion (ASD) of poorly water-soluble drugs. However …

Solid dispersion formulations by FDM 3D printing—A review

GM Khalid, N Billa - Pharmaceutics, 2022 - mdpi.com
Additive manufacturing (AM) is revolutionizing the way medicines are designed,
manufactured, and utilized. Perhaps, AM appears to be ideal for the fit-for-purpose …

Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review

J Li, Y Wang, D Yu - AAPS PharmSciTech, 2023 - Springer
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …