Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …

Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused
by mutations in genes encoding the basement membrane component laminin-332 …

There is a high demand for developing methods to produce more native-like 3D corneal
structures. In the present study, we produced 3D cornea-mimicking tissues using human …

Executive summary In this Commission, we argue that a combination of poor quality science,
unclear funding models, unrealistic hopes, and unscrupulous private clinics threatens …

Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …

Gene therapy, cell therapy, and tissue engineering have the potential to revolutionize the
treatment of disease and injury. Attaining marketing authorization for such advanced therapy …

Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of
cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and …

Burn wound healing involves a series of complex processes which are subject to intensive
investigations to improve the outcomes, in particular, the healing time and the quality of the …