The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are
involved in a wide variety of physiological functions, especially in nervous systems. Their …

Pain is a quite frequent complaint accompanying numerous pathologies. Among these
pathological cases, numerous neuropathies are retrieved with identified etiologies …

Traumatic brain injury (TBI) is a leading cause of death and disability in the United States.
Despite more than 30 years of research, no pharmacological agents have been identified …

How nature discriminates sodium from calcium ions in eukaryotic channels has been difficult
to resolve because they contain four homologous, but markedly different repeat domains …

Intracellular Ca2+ transient is crucial in initiating the differentiation of mesenchymal cells into
chondrocytes, but whether voltage-gated Ca2+ channels are involved remains uncertain …

The role of T-type calcium channels is well established in excitable cells, where they preside
over action potential generation, automaticity, and firing. They also contribute to intracellular …

The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was
a limiting factor in the evolution of nervous systems. Two rounds of domain duplications …

The progression from one to three to 10, and in some instances more, voltage‐gated
calcium channels within living organisms during the course of evolution has paralleled the …

Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous
system, but little is known about when or how their unique properties and cellular roles …