Mechanisms and clinical implications of endothelial dysfunction in arterial hypertension

P Ambrosino, T Bachetti, SE D'Anna… - Journal of …, 2022 - mdpi.com
The endothelium is composed of a monolayer of endothelial cells, lining the interior surface
of blood and lymphatic vessels. Endothelial cells display important homeostatic functions …

The contribution of gut microbiota and endothelial dysfunction in the development of arterial hypertension in animal models and in humans

J Maiuolo, C Carresi, M Gliozzi, R Mollace… - International Journal of …, 2022 - mdpi.com
The maintenance of the physiological values of blood pressure is closely related to
unchangeable factors (genetic predisposition or pathological alterations) but also to …

Controllable release of nitric oxide from an injectable alginate hydrogel

G Zheng, R Li, P Wu, L Zhang, Y Qin, S Wan… - International Journal of …, 2023 - Elsevier
Currently, the controlled release of nitric oxide (NO) plays a crucial role in various
biomedical applications. However, injectable NO-releasing materials remain an …

Coronary microvascular dysfunction and hypertension: a bond more important than we think

M Zdravkovic, V Popadic, S Klasnja, A Klasnja… - Medicina, 2023 - mdpi.com
Coronary microvascular dysfunction (CMD) is a clinical entity linked with various risk factors
that significantly affect cardiac morbidity and mortality. Hypertension, one of the most …

Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

I Belenichev, O Popazova, N Bukhtiyarova… - Antioxidants, 2024 - mdpi.com
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …

A comparison of rat models that best mimic immune-driven preeclampsia in humans

F Jahan, G Vasam, Y Cariaco, A Nik-Akhtar… - Frontiers in …, 2023 - frontiersin.org
Preeclampsia (PE), a hypertensive pregnancy disorder, can originate from varied etiology.
Placenta malperfusion has long been considered the primary cause of PE. However, we and …

Animal models of hypertension: the status of nitric oxide and oxidative stress and the role of the renal medulla

M Kuczeriszka, K Wąsowicz - Nitric Oxide, 2022 - Elsevier
Hypertension significantly contributes to overall morbidity and mortality worldwide, and
animal models of hypertension provide important tools to verify the physiological and …

Pathophysiology and therapeutic options for cirrhotic portal hypertension

S Guixé-Muntet, S Quesada-Vázquez… - The Lancet …, 2024 - thelancet.com
Portal hypertension represents the primary non-neoplastic complication of liver cirrhosis and
has life-threatening consequences, such as oesophageal variceal bleeding, ascites, and …

The phthalic selenoanhydride decreases rat blood pressure and tension of isolated mesenteric, femoral and renal arteries

P Balis, A Berenyiova, A Misak, M Grman, Z Rostakova… - Molecules, 2023 - mdpi.com
Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive
selenium species including H2Se. It is a potential compound for Se supplementation which …

Low density lipoprotein oxidized under lysosomal conditions decreases arterial vasodilatation

HKM Alboaklah, AJ McNeish, DS Leake - Free Radical Research, 2024 - Taylor & Francis
Endothelial dysfunction is a risk factor for atherosclerosis and includes impaired
endothelium-dependent vasodilatation. We have shown previously that low density …