Preeclampsia (PE) is a complex disorder that is characterized by hypertension and
proteinuria after the 20th week of pregnancy, and it causes most neonatal morbidity and …

The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms
used to interpret DNA sequencing results. It is an essential quality control component of …

Cell-free circulating DNA (cfDNA) in plasma has gained global interest as a diagnostic
material for noninvasive prenatal testing and cancer diagnosis, or the so-called “liquid …

A paradigm shift in noninvasive prenatal screening has been made with the discovery of cell-
free fetal DNA in maternal plasma. Noninvasive prenatal screening is primarily used to …

Cell-free DNA (cfDNA) has pioneered the development of noninvasive prenatal testing and
liquid biopsy, its emerging applications include organ transplantation, autoimmune …

The identification of cell‐free fetal DNA circulating in maternal blood combined with
technological developments, in particular next‐generation sequencing, is enabling the …

Preimplantation genetic testing (PGT) is increasingly used worldwide. It currently entails the
use of invasive techniques, ie polar body, blastomere, trophectoderm biopsy or …

Background Noninvasive prenatal screening (NIPS) based on cell-free fetal DNA (cffDNA)
has rapidly been applied into clinic. However, the reliability of this method largely depends …

Background Pregnant people have a risk of carrying a fetus affected by a chromosomal
anomaly. Prenatal screening is offered to pregnant people to assess their risk. Noninvasive …

Purpose The percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived
(the fetal fraction; FF) is a key driver of the sensitivity and specificity of noninvasive prenatal …