Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

The type III secretion system of Pseudomonas aeruginosa: infection by injection

AR Hauser - Nature Reviews Microbiology, 2009 - nature.com
Abstract The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III
secretion apparatus to inject effector proteins into host cells. The configuration of this …

Role of Pseudomonas aeruginosa type III effectors in disease

J Engel, P Balachandran - Current opinion in microbiology, 2009 - Elsevier
Pseudomonas aeruginosa uses a type III secretion system (T3SS) to directly inject four
known effectors into host cells. ExoU is a potent cytotoxin with phospholipase A2 activity that …

Functional domains and motifs of bacterial type III effector proteins and their roles in infection

P Dean - FEMS microbiology reviews, 2011 - academic.oup.com
A key feature of the virulence of many bacterial pathogens is the ability to deliver effector
proteins into eukaryotic cells via a dedicated type three secretion system (T3SS). Many …

Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses

SJ Wood, JW Goldufsky, MY Seu, AH Dorafshar… - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is one of the most virulent opportunistic Gram-negative bacterial
pathogens in humans. It causes many acute and chronic infections with morbidity and …

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

M Ruffin, E Brochiero - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Epithelial tissues protecting organs from the environment are the first-line of defense against
pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain …

Contribution of an arsenal of virulence factors to pathogenesis of Pseudomonas aeruginosa infections

T Strateva, I Mitov - Annals of microbiology, 2011 - Springer
Pseudomonas aeruginosa is an increasingly prevalent opportunistic pathogen that causes a
variety of nosocomial infections, life-threatening diseases in immunocompromised persons …

Structure and function of the Type III secretion system of Pseudomonas aeruginosa

M Galle, I Carpentier, R Beyaert - Current protein and peptide …, 2012 - ingentaconnect.com
Pseudomonas aeruginosa is a dangerous pathogen particularly because it harbors multiple
virulence factors. It causes several types of infection, including dermatitis, endocarditis, and …

Targeting the type three secretion system in Pseudomonas aeruginosa

A Anantharajah, MP Mingeot-Leclercq… - Trends in …, 2016 - cell.com
The injectisome type three secretion system (T3SS) is a major virulence factor in
Pseudomonas aeruginosa. This bacterium is responsible for severe infections in …

RNA Interference Screen Identifies Abl Kinase and PDGFR Signaling in Chlamydia trachomatis Entry

CA Elwell, A Ceesay, JH Kim, D Kalman… - PLoS …, 2008 - journals.plos.org
To elucidate the mechanisms involved in early events in Chlamydia trachomatis infection,
we conducted a large scale unbiased RNA interference screen in Drosophila melanogaster …