• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

SGLT2 (sodium-glucose cotransporter 2) inhibitors interfere with the reabsorption of glucose
and sodium in the early proximal renal tubule, but the magnitude and duration of any …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The American College of Cardiology (ACC) has a long history of developing documents (eg,
decision pathways, health policy statements, appropriate use criteria) to provide members …

Episodes of worsening symptoms and signs characterize the clinical course of patients with
chronic heart failure (HF). These events are associated with poorer quality of life, increased …

Abstract Background and Aims In the ADVOR trial, acetazolamide improved decongestion in
acute decompensated heart failure (ADHF). Whether the beneficial effects of acetazolamide …

Worsening heart failure (WHF) is a severe and dynamic condition characterized by
significant clinical and hemodynamic deterioration. It is characterized by worsening HF …

Aims In patients with acute heart failure (AHF), the addition of hydrochlorothiazide (HCTZ) to
furosemide improved diuretic response in the CLOROTIC trial. This work aimed to evaluate if …

Despite worsening heart failure (HF) being extremely common, expensive, and associated
with substantial risk of death, there remain no dedicated clinical practice guidelines for the …

Congestion is a key pathophysiological feature of heart failure (HF) syndrome that drives
most of the clinical manifestations of acute HF and is related with poor quality of life and …