Tools used to assay genomic instability in cancers and cancer meiomitosis

J Gantchev, B Ramchatesingh… - Journal of Cell …, 2022 - Wiley Online Library
Genomic instability is a defining characteristic of cancer and the analysis of DNA damage at
the chromosome level is a crucial part of the study of carcinogenesis and genotoxicity …

Use of micronucleus assays for the prediction and detection of cervical cancer: a meta-analysis

T Setayesh, M Kundi, A Nersesyan, H Stopper… - …, 2020 - academic.oup.com
Cervical cancer (CC) is the fourth most common cancer in women; the survival rates depend
strongly on its early detection. The Pap test is the most frequently used diagnostic tool, but …

Micronuclei and disease–Report of HUMN project workshop at Rennes 2019 EEMGS conference

M Fenech, N Holland, M Kirsch-Volders… - … /Genetic Toxicology and …, 2020 - Elsevier
Abstract The “Micronuclei and Disease” workshop was organized by the HUMN Project
consortium and hosted by the European Environmental Mutagen and Genomics Society at …

Smoking causes induction of micronuclei and other nuclear anomalies in cervical cells

A Nersesyan, R Muradyan, M Kundi, M Fenech… - International Journal of …, 2020 - Elsevier
Introduction Smoking is an independent cause of cervical cancer, which is the 4th most
common malignancy in women. It is currently not known if tobacco consumption causes …

[HTML][HTML] Association between micronucleus frequency and cervical intraepithelial neoplasia grade in Thinprep cytological test and its significance

YH Shi, BW Wang, T Tuokan, QZ Li… - International Journal of …, 2015 - ncbi.nlm.nih.gov
A micronucleus is an additional small nucleus formed due to chromosomes or chromosomal
fragments fail to be incorporated into the nucleus during cell division. In this study, we …

Assessment of the association between micronuclei and the degree of uterine lesions and viral load in women with human papillomavirus

ML Adam, C Pini, S Tulio… - Cancer Genomics & …, 2015 - cgp.iiarjournals.org
Infection by human papillomavirus (HPV) is among the main etiologies of cervical cancer.
The expression of oncogenic viral proteins enables the onset of the virus, which can trigger …

Association between human papillomavirus (HPV) DNA and micronuclei in normal cervical cytology

APR Cassel, RB Barcellos, CMD Silva… - … and Molecular Biology, 2014 - SciELO Brasil
The aim of the present study was to investigate the association between HPV-DNA and
micronucleus (MN) frequency in women with normal cervical cytology. A total of 158 normal …

Cytokinesis-block micronucleus assay adapted for analyzing genomic instability of human mesenchymal stem cells

DA Cornélio, JCM Tavares, TVCA Pimentel… - Stem cells and …, 2014 - liebertpub.com
Human mesenchymal stem cells (hMSCs) are multipotent cells used in cell therapy
research. One of the problems involving hMSCs is the possibility of genetic instability during …

Impact of infections, preneoplasia and cancer on micronucleus formation in urothelial and cervical cells: A systematic review

T Setayesh, A Nersesyan, M Kundi, M Mišík… - … Research/Reviews in …, 2021 - Elsevier
Abstract Approximately 165,000 and 311,000 individuals die annually from urothelial (UC)
and cervical (CC) cancer. The therapeutic success of these cancers depends strongly on …

The Causes and Consequences of DNA Damage and Chromosomal Instability Induced by Human Papillomavirus

KM Jones, A Bryan, E McCunn, PE Lantz, H Blalock… - Cancers, 2024 - mdpi.com
Simple Summary Human papillomavirus (HPV) causes 5% of cancers and is the main cause
of oropharyngeal cancer in the United States and of cervical cancer worldwide. HPV …