The CCAAT box is one of the most common elements in eukaryotic promoters, found in the
forward or reverse orientation. Among the various DNA binding proteins that interact with …

Lipoproteins are macromolecular complexes of lipids and proteins which originate mainly
from the liver and intestine, and are involved in the transport and redistribution of lipids in the …

Apolipoproteins B, CIII, and AII are synthesized primarily in the liver and intestine and play
an important role in lipid and cholesterol metabolism. It was previously shown that the cis …

The regulation of liver apolipoprotein (apo) AI gene expression by fibrates was studied in
human apo AI transgenic mice containing a human genomic DNA fragment driving apo AI …

Btk is a critical molecule in B cell antigen receptor (BCR)-coupled signaling, and its activity is
regulated by Lyn and Syk. Although the molecular mechanism of Lyn-dependent Btk …

Over the past years, evidence has been accumulating for a fundamental role of protein-
protein interactions between transcription factors in gene-specific transcription regulation …

Epidemiological studies have demonstrated that the risk of coronary artery disease (CAD) is
increased in smokers but reduced in individuals with elevated plasma levels of high density …

We investigated a common polymorphism in the human apolipoprotein AI gene promoter at
a position 76 bp upstream of the transcriptional start site. 54 human subjects, whose apoAI …

The orphan nuclear receptor liver receptor homolog-1 (LRH-1) has been reported to play a
role in bile acid biosynthesis and reverse cholesterol transport. In this study, we examined …

The present review summarizes recent advances in the transcriptional regulation of the
human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and …