Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
developing embryo but remains ill-defined in humans. We therefore assembled a …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …

Macrophage‐myofibroblast transition (MMT) is a newly discovered pathway for mass
production of pro‐tumoral cancer‐associated fibroblasts (CAFs) in non‐small cell lung …

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

Most organs have tissue-resident immune cells. Human organoids lack these immune cells,
which limits their utility in modeling many normal and disease processes. Here, we describe …

Hematopoietic stem cells (HSCs) are the rare cells responsible for the lifelong curative
effects of hematopoietic cell (HC) transplantation. The demand for clinical-grade HSCs has …