Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves
in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) …

In contrast to newborns, who spend 16–20 h in sleep each day, adults need only about
sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition …

Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity
and quality occur as we age, and are there functional consequences? What are the …

The coupled interaction between slow-wave oscillations and sleep spindles during non-
rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation …

The proposed mechanisms of sleep-dependent memory consolidation involve the overnight
regulation of neural activity at both synaptic and whole-network levels. Now, there is a lack …

In Alzheimer's disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by
intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic …

Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are
prominent states of reduced arousal linked to the occurrence of synchronized oscillations in …