Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …

The bioavailability of an orally administered small molecule is often dictated by drug-specific
physicochemical characteristics and is influenced by many biological processes. For …

Proper medication dissolution must be ensured when developing or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …

Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue
distribution of small molecules to prolong their systemic circulation, target specific tissue, or …

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Introduction: Oral drug delivery is the most favored route of drug administration. However …

The diversity of lipid excipients available commercially has enabled versatile formulation
design of lipid-based drug delivery systems for enhancing the oral absorption of poorly …

Personalized medicine strives to deliver the 'right drug at the right dose'by considering inter-
person variability, one of the causes for therapeutic failure in specialized populations of …