The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …

Viruses have been a long-term source of infectious diseases that can lead to large-scale
infections and massive deaths. Especially with the recent highly contagious coronavirus …

We review various mathematical and computational techniques for drug discovery
exemplifying some recent works pertinent to group theory of nested structures of relevance …

With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in
the arena of medicine. Out of the various drug targets involved in managing RNA-viral …

Heterocyclic compounds are that type of substances that are deeply intertwined with
biological processes. Heterocycles are found in about 90% of commercially available …

In terms of fused heterocyclic compounds, pyrrolopyrimidines, and their substituted analogs
are among the most extensively explored scaffolds. Based on the location of the nitrogen …

New three-component domino reactions, providing divergent approaches to
multifunctionalized pyrroles with different substitution patterns, have been established (47 …

The aim of the present study is to use [125 I] iododomperidone (125 I-DOM) as a novel
radioligand for dopamine D2-receptor (D2R) imaging. Therefore, a 12 h in vitro stable [125 I] …

In this work we described the synthesis and evaluation of cytotoxic and apoptotic activity of
novel pyrrolopyrimidine derivatives against A549, PC3 and MCF-7 cells. Among the …

For several decades, interest in the synthesis pyrrole and pyrrolopyrimidine increases due to
the importance of these heterocycles both from chemical and biological points of view. They …