An update on the role of cardiorespiratory fitness, structured exercise and lifestyle physical activity in preventing cardiovascular disease and health risk
The cardiovascular disease (CVD) pandemic has placed considerable strain on healthcare
systems, quality of life, and physical function, while remaining the leading cause of death …
systems, quality of life, and physical function, while remaining the leading cause of death …
Moving Beyond the Sarcomere to Explain Heterogeneity in Hypertrophic Cardiomyopathy: JACC Review Topic of the Week
BJ Maron, MS Maron, BA Maron, J Loscalzo - Journal of the American …, 2019 - jacc.org
Hypertrophic cardiomyopathy (HCM) has been considered a heterogeneous cardiac
disease ascribed solely to single sarcomere gene mutations. However, limitations of this …
disease ascribed solely to single sarcomere gene mutations. However, limitations of this …
[HTML][HTML] Towards revolutionizing precision healthcare: A systematic literature review of artificial intelligence methods in precision medicine
In the realm of medicine, artificial intelligence (AI) has emerged as a transformative force,
harnessing the power to convert raw data into meaningful insights. Rather than supplanting …
harnessing the power to convert raw data into meaningful insights. Rather than supplanting …
Harnessing big data to advance treatment and understanding of pulmonary hypertension
Pulmonary hypertension is a complex disease with multiple causes, corresponding to
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …
The application of big data to cardiovascular disease: paths to precision medicine
JA Leopold, BA Maron, J Loscalzo - The Journal of clinical …, 2020 - Am Soc Clin Investig
Advanced phenotyping of cardiovascular diseases has evolved with the application of high-
resolution omics screening to populations enrolled in large-scale observational and clinical …
resolution omics screening to populations enrolled in large-scale observational and clinical …
Immunoglobulin-driven complement activation regulates proinflammatory remodeling in pulmonary hypertension
MG Frid, BA McKeon, JM Thurman… - American journal of …, 2020 - atsjournals.org
Rationale: Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disorder in
which inflammation and immunity have emerged as critical early pathogenic elements …
which inflammation and immunity have emerged as critical early pathogenic elements …
Cardiac risk stratification in cancer patients: A longitudinal patient–patient network analysis
Background Cardiovascular disease is a leading cause of death in general population and
the second leading cause of mortality and morbidity in cancer survivors after recurrent …
the second leading cause of mortality and morbidity in cancer survivors after recurrent …
[HTML][HTML] Network medicine in pathobiology
LYH Lee, J Loscalzo - The American Journal of Pathology, 2019 - Elsevier
The past decade has witnessed exponential growth in the generation of high-throughput
human data across almost all known dimensions of biological systems. The discipline of …
human data across almost all known dimensions of biological systems. The discipline of …
Strengths and opportunities of network medicine in cardiovascular diseases
G Benincasa, R Marfella, N Della Mura… - Circulation …, 2020 - jstage.jst.go.jp
Network medicine can advance current medical practice by arising as response to the
limitations of a reductionist approach focusing on cardiovascular (CV) diseases as a direct …
limitations of a reductionist approach focusing on cardiovascular (CV) diseases as a direct …
Network medicine in Cardiovascular Research
The ability to generate multi-omics data coupled with deeply characterizing the clinical
phenotype of individual patients promises to improve understanding of complex …
phenotype of individual patients promises to improve understanding of complex …