Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …

Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may
show signs of premature/accentuated aging. We compared established biomarkers of aging …

Human aging is a lifelong process characterized by a continuous trade-off between pro-and
anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic …