BACKGROUND Ever since Edward Tolman's proposal that comprehensive cognitive maps
underlie spatial navigation and, more generally, psychological functions, the question of …

Neural computations are often compared to instrument-measured distance or duration, and
such relationships are interpreted by a human observer. However, neural circuits do not …

The hippocampal-entorhinal system is important for spatial and relational memory tasks. We
formally link these domains, provide a mechanistic understanding of the hippocampal role in …

In contextual fear conditioning, experimental subjects learn to associate a neutral context
with an aversive stimulus and display fear responses to a context that predicts danger …

Since the first place cell was recorded and the cognitive-map theory was subsequently
formulated, investigation of spatial representation in the hippocampal formation has evolved …

The hippocampus is traditionally thought to transmit contextual information to limbic
structures where it acquires valence. Using freely moving calcium imaging and …

Identifying the spatial organization of tissues at cellular resolution from single-cell gene
expression profiles is essential to understanding biological systems. Using an in situ 3D …

The precise functional role of the hippocampus remains a topic of much debate. The
dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and …

Daily experience suggests that we perceive distances near us linearly. However, the actual
geometry of spatial representation in the brain is unknown. Here we report that neurons in …

The hippocampal system is critical for storage and retrieval of declarative memories,
including memories for locations and events that take place at those locations. Spatial …