Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors

KA Woll, F Van Petegem - Physiological Reviews, 2022 - journals.physiology.org
Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Structure of human Cav2.2 channel blocked by the painkiller ziconotide

S Gao, X Yao, N Yan - Nature, 2021 - nature.com
The neuronal-type (N-type) voltage-gated calcium (Cav) channels, which are designated
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …

Neuronal voltage-gated calcium channels: structure, function, and dysfunction

BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

AC Dolphin - The Journal of physiology, 2016 - Wiley Online Library
Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Voltage-gated calcium channels

WA Catterall - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Structure and pharmacology of voltage-gated sodium and calcium channels

WA Catterall, MJ Lenaeus… - Annual review of …, 2020 - annualreviews.org
Voltage-gated sodium and calcium channels are evolutionarily related transmembrane
signaling proteins that initiate action potentials, neurotransmission, excitation-contraction …

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

Structure of the voltage-gated calcium channel Cav1.1 complex

J Wu, Z Yan, Z Li, C Yan, S Lu, M Dong, N Yan - Science, 2015 - science.org
INTRODUCTION Voltage-gated Ca2+ (Cav) channels activate in response to membrane
potential changes and initiate Ca2+-mediated cellular signaling cascades. The L-type, high …