Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility

MP Dragomir, S Kopetz, JA Ajani, GA Calin - Gut, 2020 - gut.bmj.com
One of the most unexpected discoveries in molecular oncology, in the last decades, was the
identification of a new layer of protein coding gene regulation by transcripts that do not …

An insight into the arising role of MicroRNAs in hepatocellular carcinoma: future diagnostic and therapeutic approaches

E Koustas, EM Trifylli, P Sarantis… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) constitutes a frequent highly malignant form of primary liver
cancer and is the third cause of death attributable to malignancy. Despite the improvement …

NUSAP1-LDHA-Glycolysis-Lactate feedforward loop promotes Warburg effect and metastasis in pancreatic ductal adenocarcinoma

M Chen, K Cen, Y Song, X Zhang, YC Liou, P Liu… - Cancer Letters, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and hypovascular
tumor microenvironment. Nucleolar and spindle associated protein 1 (NUSAP1) is a …

[HTML][HTML] Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

K Johnson, PJ Leary, O Govaere, MJ Barter… - JHEP Reports, 2022 - Elsevier
Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic
fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile …

Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis

M Liu, F Mo, X Song, Y He, Y Yuan, J Yan, Y Yang… - PeerJ, 2021 - peerj.com
Purpose Breast cancer (BC) is characterized by concealed onset, delayed diagnosis, and
high fatality rates making it particularly dangerous to patients' health. The purpose of this …

Hepatocellular carcinomas, exhibiting intratumor fibrosis, express cancer-specific extracellular matrix remodeling and WNT/TGFB signatures, associated with poor …

R Desert, W Chen, X Ge, R Viel, H Han, D Athavale… - Hepatology, 2023 - journals.lww.com
Hepatocellular carcinomas, exhibiting intratumor fibrosis, e... : Hepatology Hepatocellular
carcinomas, exhibiting intratumor fibrosis, express cancer-specific extracellular matrix …

[HTML][HTML] Identification of potential hub genes related to the progression and prognosis of hepatocellular carcinoma through integrated bioinformatics analysis

X Song, R Du, H Gui, M Zhou, W Zhong… - Oncology …, 2020 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‑related deaths among
cancer patients. Genes correlated with the progression and prognosis of HCC are critically …

NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR

Y Zhao, J He, Y Li, S Lv, H Cui - Signal transduction and targeted …, 2020 - nature.com
NUSAP1, which is a microtubule-associated protein involved in mitosis, plays essential roles
in diverse biological processes, especially in cancer biology. In this study, NUSAP1 was …

Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

H Li, W Zhang, M Yan, J Qiu, J Chen, X Sun… - Journal of Experimental …, 2019 - Springer
Background The primary obstacle to treat cervical cancer is its high prevalence of
metastasis, which severely affects patients' quality of life and survival time. Nucleolar and …

miR-125 inhibits colorectal cancer proliferation and invasion by targeting TAZ

M Yang, X Tang, Z Wang, X Wu, D Tang… - Bioscience …, 2019 - portlandpress.com
Colorectal cancer (CRC) is the third most common malignant tumor worldwide and is a
serious threat to human health. MicroRNAs (miRNAs) play a key role in oncogenesis and …