This scientific statement presents considerations for clinical management regarding the
assessment and risk reduction of select pediatric populations at high risk for premature …

Heart failure (HF) is an important cardiovascular disease because of its increasing
prevalence, significant morbidity, high mortality, and rapidly expanding health care cost. The …

Cochrane, Maria Crespo Leiro, Anne Dipchand, Brian Feingold, Kathleen Grady, Edward
Horn, Maryl Johnson, Donna Mancini, Sean Pinney, Heather Ross, Kari Wujcik, Andreas …

Heart transplantation (HTx) has become standard treatment for selected patients with end-
stage heart failure. Improvements in immunosuppressant, donor procurement, surgical …

The purine nucleotides ATP and GTP are essential precursors to DNA and RNA synthesis
and fundamental for energy metabolism. Although de novo purine nucleotide biosynthesis is …

In 2014, the Immunosuppressive Drugs Scientific Committee of the International Association
of Therapeutic Drug Monitoring and Clinical Toxicology called a meeting of international …

Abstract Purpose of Review The purpose of this review is to provide a comprehensive
update on recent advances in heart transplantation. Recent Findings Heart transplantation is …

Background: Small studies have reported superiority of sirolimus (SRL) over calcineurin
inhibitor (CNI) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation …

Since the first heart transplantation (HT) in 1967, survival has steadily improved. Issues
related to over-and under-immunosuppression are, however, still common following HT …

In a randomized, open-label trial, de novo heart transplant recipients were randomized to
everolimus (3–6 ng/mL) with reduced-exposure calcineurin inhibitor (CNI; cyclosporine) to …