Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
All organisms possess molecular mechanisms that govern DNA repair and associated DNA
damage response (DDR) processes. Owing to their relevance to human disease, most …
damage response (DDR) processes. Owing to their relevance to human disease, most …
DNA replication: Mechanisms and therapeutic interventions for diseases
HY Song, R Shen, H Mahasin, YN Guo, DG Wang - MedComm, 2023 - Wiley Online Library
Accurate and integral cellular DNA replication is modulated by multiple replication‐
associated proteins, which is fundamental to preserve genome stability. Furthermore …
associated proteins, which is fundamental to preserve genome stability. Furthermore …
Exploring the structural landscape of DNA maintenance proteins
Evolutionary annotation of genome maintenance (GM) proteins has conventionally been
established by remote relationships within protein sequence databases. However, often no …
established by remote relationships within protein sequence databases. However, often no …
Co-evolution based machine-learning for predicting functional interactions between human genes
Over the next decade, more than a million eukaryotic species are expected to be fully
sequenced. This has the potential to improve our understanding of genotype and phenotype …
sequenced. This has the potential to improve our understanding of genotype and phenotype …
Mechanism of DNA unwinding by MCM8-9 in complex with HROB
A Acharya, H Bret, JW Huang, M Mütze, M Göse… - Nature …, 2024 - nature.com
HROB promotes the MCM8-9 helicase in DNA damage response. To understand how
HROB activates MCM8-9, we defined their interaction interface. We showed that HROB …
HROB activates MCM8-9, we defined their interaction interface. We showed that HROB …
Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells
Replication timing regulatory factor 1 (RIF1) acts downstream of p53-binding protein 53BP1
to inhibit the resection of DNA broken ends, which plays critical roles in determining the DNA …
to inhibit the resection of DNA broken ends, which plays critical roles in determining the DNA …
PICKLES v3: the updated database of pooled in vitro CRISPR knockout library essentiality screens
LC Novak, J Chou, M Colic, CA Bristow… - Nucleic acids …, 2023 - academic.oup.com
Abstract PICKLES (https://pickles. hart-lab. org) is an updated web interface to a freely
available database of genome-scale CRISPR knockout fitness screens in human cell lines …
available database of genome-scale CRISPR knockout fitness screens in human cell lines …
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis
Ferroptosis has been recognized as a unique cell death modality driven by excessive lipid
peroxidation and unbalanced cellular metabolism. In this study, we established a protein …
peroxidation and unbalanced cellular metabolism. In this study, we established a protein …
Low-molecular-weight cyclin E deregulates DNA replication and damage repair to promote genomic instability in breast cancer
Low-molecular-weight cyclin E (LMW-E) is an N-terminus deleted (40 amino acid) form of
cyclin E detected in breast cancer, but not in normal cells or tissues. LMW-E overexpression …
cyclin E detected in breast cancer, but not in normal cells or tissues. LMW-E overexpression …
Exploiting the DNA Damage Response for Prostate Cancer Therapy
Simple Summary Localized prostate cancer has a favorable prognosis and can be
effectively treated with radiotherapy, as well as therapies that target hormone production and …
effectively treated with radiotherapy, as well as therapies that target hormone production and …